Zinc oxide NPs can be synthesized by a number of physical, chemical and biological methods. Zitao Zhou, Jino Son, Bryan Harper, Zheng Zhou, Stacey Harper, Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish, Beilstein Journal of Nanotechnology, 10.3762/bjnano.6.160, 6, (1568-1579), (2015). However, their potential toxicological impact on environmental microorganisms is largely unexplored. Nanoscale. Epub 2016 Jun 7. Copyright © 2017 Elsevier B.V. All rights reserved. neuronal or epithelial cells). This study investigates the toxic effects of ZnO-NPs in human lung cells. Uzar NK, Abudayyak M, Akcay N, Algun G, Özhan G. Toxicol Mech Methods. A combined toxicity study of zinc oxide nanoparticles and vitamin C in food additives. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area … In-Vitro cytotoxicity, antibacterial, and UV protection properties of the biosynthesized Zinc oxide nanoparticles for medical textile applications. ZnO nanopowders are available as powders and dispersions.  |  10.1166/jnn.2010.2483. Zinc oxide nanocomposites show also selective toxicity toward normal and cancerous cells, which is explained by reactive oxygen formation (ROS). CAS Article PubMed Google Scholar Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism View 0 peer reviews of Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism on Publons COVID-19 : add an open review or score for a COVID-19 paper now to ensure the latest research gets the extra scrutiny it needs. Hidden toxicity of zinc oxide nanoparticles. This paper reviews the methods of synthesizing zinc oxide nanocomposites as well as their characteristics, antimicrobial activity and cytotoxicity against normal and tumor cells. Please enable it to take advantage of the complete set of features! J Photochem Photobiol B. They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties. Abbasalipourkabir R, Moradi H, Zarei S, Asadi S, Salehzadeh A, Ghafourikhosroshahi A, Mortazavi M, Ziamajidi N. Food Chem Toxicol. Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Zinc oxide nanoparticles have also been tested for longer-term toxicity in animals, using both skin tests and experiments in which suspended particles are inhaled. 2015;25(4):334-9. doi: 10.3109/15376516.2015.1045654. A severe to slight damage was observed in liver tissue … Environmental Science and Pollution Research 2019 , 26 (3) , … Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. There is a single study of repeated skin exposure in rats (ten per cent of body area treated for five days a week, over four weeks). Biotechnological aspects of ZnO nanoparticles: overview on synthesis and its applications. HHS NLM acute and chronic doses; blood parameters; liver tissue.  |  DOI: 10.1007/s40820-015-0040-x Corpus ID: 3669662. Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism @article{Sirelkhatim2015ReviewOZ, title={Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism}, author={Amna Sirelkhatim and S. Mahmud and A. Seeni and Noor Haida Mohamad Kaus and Ling Chuo Ann and S. K. M. Bakhori and … ZnO NPs exhibit attractive antimicrobial properties against bacteria (Gram-positive and Gram-negative) and fungi. J Nanosci Nanotechnol 2010, 10: 8617–8624. While their general toxicity and associated oxidative stress have been extensively studied, the toxicological pathways that they induce in developmental stages are still largely unknown. Zinc oxide nanocomposites show also selective toxicity toward normal and cancerous cells, which is explained by reactive oxygen formation (ROS). 2015 Oct;84:154-60. doi: 10.1016/j.fct.2015.08.019. Keywords: Zinc is a Block D, Period 4 element, while Oxygen is a Block P, Period 2 element. 8, Ref. Corrigendum to "Zinc oxide nanoparticles: synthesis, antiseptic activity and toxicity mechanism" Adv Colloid Interface Sci 249 (2017) 37-52. Biosynthesis of zinc oxide nanoparticles by cell-biomass and supernatant of Lactobacillus plantarum TA4 and its antibacterial and biocompatibility properties.  |  Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. 2012 May 2;12:60. doi: 10.1186/1472-6882-12-60. Int J Nanomedicine. Effect of annealing temperature on antimicrobial and structural properties of bio-synthesized zinc oxide nanoparticles using flower extract of Anchusa italica. While their general toxicity and associated oxidative stress have been extensively studied, the toxicological pathways that they induce in developmental stages are still largely unknown. Literatures available on ZnO nanoparticles toxicity suggest that dissolution, organism dependent cellular uptake, generation of reactive oxygen species (ROS), and induced inflammatory responses seem to be common factors which govern the toxicity of ZnO nanoparticles. eCollection 2020. Khan MF, Husain FM, Zia Q, Ahmad E, Jamal A, Alaidarous M, Banawas S, Alam MM, Alshehri BA, Jameel M, Alam P, Ahamed MI, Ansari AH, Ahmad I. ACS Omega.  |  Material and methods: In the present study 36 male Wistar rats with approximate age of two months and weighing 300±30 g were selected. 2014;6(24):15333–15342. This site needs JavaScript to work properly. 2018 Apr 25;286:60-70. doi: 10.1016/j.cbi.2018.03.008. They can also be utilized as a self-cleaning coating material on glass and ceramic surfaces. 45. Please enable it to take advantage of the complete set of features! Epub 2016 Feb 9. HHS eCollection 2020 Dec 22. Animals NLM Zinc Oxide (ZnO) is one of the most exploitable nanoparticles (NPs) in industrial and consumer products especially in cosmetics, food additives, pharmaceuticals, biosensors, photo electricity and rubber industry etc. Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. Yet despite the potentially interesting antitumor activity of ZnO nanoparticles, it has been proven that they can be also cytotoxic and genotoxic for multiple types of human cells (i.e. Microbial Fabrication of Zinc Oxide Nanoparticles and Evaluation of Their Antimicrobial and Photocatalytic Properties. This helps to place the in vivo behavior of zinc oxide nanoparticles in the proper context. It indicates an important role of Zn 2 + ions in the cytotoxicity of zinc oxide nanoparticles. Whether zinc nanoparticles (NPs) are phytotoxic or beneficial to plants remains controversial because of limited research.  |  Accute Toxicity Satureja ZnO Nanoparticles Bioassay Test LC 50 96h Abstract Nanoparticles are commonly synthesized chemically and because of their risk for living was carried out to evaluate the acute toxicity of zinc oxide nanoparticles synthesized from Satureja hortensis on rainbow trout (Oncorhynchus mykiss) by static bioassay test. ISRN Toxicol 2013; 2013: 316075. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Srivastav AK, Kumar M, Ansari NG, Jain AK, Shankar J, Arjaria N, Jagdale P, Singh D. Hum Exp Toxicol. 2018 Dec;125:252-261. doi: 10.1016/j.micpath.2018.09.030. 2018 Apr;254:100. doi: 10.1016/j.cis.2018.04.006. It has been shown that maximum exposure concentration of zinc oxide (125 mg/l) suspension released 6.8 mg/l of Zn 2+ ions. Nowadays, a lot of studies were carried out about side effects of nanoparticles especially nano-zinc oxide, but unfortunately, most of these studies have been conducted with high doses. PMID: 30489211 [Indexed for MEDLINE] Publication Types: Review; MeSH terms. Wang Y, Yuan L, Yao C, et al. eCollection 2020. Sci Rep. 2020 Nov 17;10(1):19996. doi: 10.1038/s41598-020-76402-w. Jain D, Shivani, Bhojiya AA, Singh H, Daima HK, Singh M, Mohanty SR, Stephen BJ, Singh A. Bobrowska-Korczak B, Gątarek P, Skrajnowska D, Bielecki W, Wyrebiak R, Kovalczuk T, Wrzesień R, Kałużna-Czaplińska J. Nutrients. Furthermore, zinc oxide nanoparticles induced cytotoxicity in human lung epithelial cells via inducing oxidative stress in a concentration-dependent manner, resulting in DNA damage and apoptosis [36 Sahu D, Kannan GM, Vijayaraghavan R, Anand T, Khanum F. Nanosized zinc oxide induces toxicity in human lung cells. With these it is possible to obtain information concerning the size, shape and optical properties of nanoparticles. Int J Nanomedicine. Zinc oxide nanoparticles (ZnO NPs) are being utilized in an increasing number of fields and commercial applications. The nanoparticles (NPs) have been increasingly manufactured in industry because of the well-known characteristics such as high reactivity, electromagnetic properties and high antibacterial property [].Zinc oxide nanoparticle (nZnO), one of the most popular manufactured metal oxide nanomaterials, has unique properties (i.e., surface area and reactive sites) due to the extremely small … The aim of this work was to investigate the sensitivity and adaptability of five bacterial species isolated from sewage towards Ag and ZnO NPs. There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. The ZnO nanomaterials release into the aquatic ecosystems through domestic and industrial wastewaters has the potential to induce pernicious effects on fish and other organisms. Microb Pathog. COVID-19 is an emerging, rapidly evolving situation. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. 30 nm) showed that small particles in aquatic systems and their bioavailability does not have to be significantly greater than that of larger particles. The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. ; nano-zinc oxide; oxidative stress. We evaluate the potential of zinc oxide nanoparticles as innovative anti-tumor agents by summarizing important results of current studies in this field and discuss the proposed mechanisms that give zinc oxide nanoparticles a selective toxicity for tumor cells. A severe to slight damage was observed in liver tissue in all groups and tissue destruction was seen in kidney only in acute dose treated groups but no specific pathological effect in testis was observed (Fig. Mechanistic study on antibacterial action of zinc oxide nanoparticles synthesized using green route.  |  The purpose of this study was to characterize the zinc oxide nanoparticles (ZnO-NPs) and their bulk counterpart in suspensions and to access the impact of their acute oral toxicity at doses of 300 and 2000 mg/kg in healthy female Wistar rats. Appl Microbiol Biotechnol. ZnO nanomaterials can be used in industry as nano-optical and nano-electrical devices, in food packaging and in medicine as antimicrobial and antitumor agents. High luminescent efficiency, a wide band gap (3.36eV), and a large exciton binding energy (60meV) has triggered intense research on the production of nanoparticles using different synthesis methods and on their future applications. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. NIH Would you like email updates of new search results? It is now widely recognized that dissolution plays an important role in metallic nanoparticle toxicity, but to what extent remains unclear. compared the toxicity of various metal oxide nanoparticles and zinc chloride to a Freshwater Microalga. Azizi S, Mohamad R, Bahadoran A, Bayat S, Rahim RA, Ariff A, Saad WZ. Zinc oxide nanoparticles (ZnO-NPs) are among nanoscale materials displaying exponentially growing production due to their applications in the field of cosmetology, medicine, as antibacterial agent and catalyst. eCollection 2019. Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. Fouda A, El-Din Hassan S, Salem SS, Shaheen TI. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 43). COVID-19 is an emerging, rapidly evolving situation. sativus) plants. After standard phases of preparation, injections were done intraperitoneally in chronic groups with zinc oxide nanoparticles (20 and 40 mg/kg) every other day and for acute groups with 200 and 400 mg/kg in a single dose. Results: Xia T, Kovochich M, Liong M, et al. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. Introduction: This kind of nanomaterial shows serious adverse effects on human respiratory system as it can pass through alveolar epithelial cells into lung … The current hazard assessment of the emerging chemical contaminant, zinc oxide nanoparticles (ZnO-NPs), seldom considers the influence of environmental factors. Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats. Antimicrobial activity; Cytotoxicity; Nanoparticles; Nanotechnology; Synthesis; Zinc oxide. The increasing focus on nano zinc oxide resulted in the invention and development of methods of nanoparticles synthesis. 2016 Jan;100(2):571-81. doi: 10.1007/s00253-015-7108-x. USA.gov. This article provides further detail on the properties and applications of zinc oxide nanoparticles (ZnO). ZnO induced toxicity in both cells, leading to the generation of reactive oxygen species (ROS), oxidant injury, excitation of inflammation, and cell death. Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. Faddah LM, Abdel Baky NA, Al-Rasheed NM, Al-Rasheed NM, Fatani AJ, Atteya M. BMC Complement Altern Med. Using ICP-MS and fluorescent-labeled ZnO, it is found that ZnO dissolution could happen in culture medium and endosomes. Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. Toxic effect of nano-zinc oxide There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. Front Chem. 2016 Aug;161:441-9. doi: 10.1016/j.jphotobiol.2016.06.007. In the present study, it was found that ZnO‐engineered nanoparticle (ZnO‐EN) toxicity to the marine diatom Thalassiosira pseudonana could be solely explained by … The obtained nanoparticles can be characterized with a broad range of analytical methods including dynamic light scattering (DLS), electron microscopy (TEM, SEM), UV-VIS spectroscopy, X-ray diffraction (XRD) or inductively coupled plasma with mass spectrometry (ICP-MS). 2020 Nov 11;12(11):3457. doi: 10.3390/nu12113457. 2016 Dec;35(12):1286-1304. doi: 10.1177/0960327116629530. 2014 Nov;33(11):1150-7. doi: 10.1177/0960327113510327. Król A, Pomastowski P, Rafińska K, Railean-Plugaru V, Buszewski B. Adv Colloid Interface Sci. Epub 2018 Sep 18. Would you like email updates of new search results? Zinc oxide nanoparticles are nanoparticles of zinc oxide (ZnO) that have diameters less than 100 nanometers. Amara S, Slama IB, Mrad I, Rihane N, Khemissi W, El Mir L, Rhouma KB, Abdelmelek H, Sakly M. Hum Exp Toxicol. Epub 2015 May 18. Epub 2015 Nov 6. 2020 Sep 30;8:778. doi: 10.3389/fchem.2020.00778. After the determined time for every group (21 days for chronic groups and 7 days for acute groups), blood samples were provided from rat hearts and also liver, kidney and testicular tissue were removed for histological studies. 2020 Oct 2;15:7329-7358. doi: 10.2147/IJN.S265934. Clipboard, Search History, and several other advanced features are temporarily unavailable. Zinc oxide nanoparticles (ZnO-NPs) have been reported as an antimicrobial agent against both pathogenic and spoilage microorganisms ... L. C., Bakhori, S. K. M., Mohamad, D., Review on zinc oxide nanoparticles: Antibacterial activity and toxicity mechanism. USA.gov. Zinc oxide nanoparticles (ZnO NPs) are being utilized in an increasing number of fields and commercial applications. Yet despite the potentially interesting antitumor activity of ZnO nanoparticles, it has been proven that they can be also cytotoxic and genotoxic for multiple types of human cells (i.e. However, under seasonal variation and global climate change, marine organisms are exposed to a changing environment with different regimes of temper Environmental Science: Nano Recent HOT Articles Several studies of ZnO NPs cytotoxicity have been conducted and they have shown that zinc oxide nanoparticles can affect many different animal cells , , , , , , , , , . 2020 Dec 10;5(50):32203-32215. doi: 10.1021/acsomega.0c03634. Biosynthesis of zinc oxide nanoparticles using. Zinc oxide nanoparticles induced cyto- and genotoxicity in kidney epithelial cells. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. Zinc oxide (ZnO) has been characterized as a “Generally Recognized as Safe” (GRAS) compound by the US FDA and exhibits minimal toxicity to humans. Epub 2014 Feb 5. Mohd Yusof H, Abdul Rahman N, Mohamad R, Zaidan UH, Samsudin AA. Nano-Micro Letters, 7, 219-242 (2015). Silver and zinc oxide nanoparticles (Ag and ZnO NPs) are widely used as antimicrobial agents. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes. This site needs JavaScript to work properly. Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney. RESEARCH ARTICLE Zinc oxide and silver nanoparticles toxicity in the baker’s yeast, Saccharomyces cerevisiae Imelda Galva´ n Ma´ rquez1, Mergan Ghiyasvand1, Andrey Massarsky2¤, Mohan Babu3, Bahram Samanfar1,4, Katayoun Omidi1, Thomas W. Moon2, Myron L. Smith1*, Ashkan Golshani1* 1 Department of Biology and Ottawa Institute of Systems Biology, Carleton University, … Epub 2018 Mar 15. 2018 Dec 20;14:87-100. doi: 10.2147/IJN.S186888. NIH Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Wang LJ, Wang L, Ding WJ, Zhang F: Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats. Epub 2015 Aug 24. A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats: Toxicity study of zinc oxide nanoparticles. The impact of morphology and size of zinc oxide nanoparticles on its toxicity to the freshwater microalga, Raphidocelis subcapitata. Franklinet al. Clipboard, Search History, and several other advanced features are temporarily unavailable. Toxicity of zinc oxide nanoparticles through oral route Surekha Pasupuleti, Srinivas Alapati, Selvam Ganapathy, Goparaju Anumolu, Neelakanta Reddy Pully, and Balakrishna Murthy Prakhya Toxicology and Industrial Health 2011 28 : 8 , 675-686 In this study, we investigated the effect of various concentrations of zinc oxide (ZnO) NPs (0, 1, 5, 20, 100, and 1000 mg kg −1 of soil) on lettuce (Lactuca sativa L.) and carrot (Daucus carota subsp. Zinc oxide (ZnO) has long been recognized as an effective sunscreen agent. Happy Agarwal, Soumya Menon, Venkat Kumar S, Rajeshkumar S. Chem Biol Interact. Keywords: Recently, various approaches including physical, chemical and biological ("green chemistry") have been used to prepare ZnO nanocomposites with different morphologies. The study used nanoparticulate ZnO (ca. neuronal or epithelial cells). Toxicity of zinc oxide nanoparticles on adult male Wistar rats. 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The zinc oxide nanoparticles toxicity of toxicity of various metal oxide nanoparticles in the aqueous medium widely used antimicrobial. Of two months and weighing 300±30 g were selected 2020 Nov 11 ; (... Rats: toxicity study of zinc oxide nanoparticles induced cyto- and genotoxicity in kidney epithelial cells ZnO-NPs,!, which is explained by reactive oxygen formation ( ROS ) S. Biol! The cytotoxicity of zinc oxide nanoparticles and vitamin C in food additives synthesized! As Antibiotics Substitutes the Serum Metabolites Profile at the Early Stage of Breast Cancer in rats zinc chloride to Freshwater!